Azonox 100 | 6pcs Capsule

✔️ Itraconazole is indicated for:

Systemic Mycoses:

• Blastomycosis
• Histoplasmosis (non-meningeal)
• Aspergillosis (for patients intolerant/refractory to amphotericin B)
• Cryptococcosis (meningeal and disseminated)
• Paracoccidioidomycosis
• Coccidioidomycosis
• Sporotrichosis, chromomycosis, leishmaniasis, fungal keratitis, zygomycosis

Superficial Mycoses:

• Onychomycosis (fingernail/toenail fungal infections)
• Dermatophytoses (tinea capitis, tinea corporis, tinea cruris, tinea pedis)
• Pityriasis versicolor
• Sebopsoriasis
• Vulvovaginal and chronic mucocutaneous candidiasis

✔️ Side Effects | Azonox 100

Common: Nausea, vomiting, abdominal pain, diarrhea, headache, dizziness, blurred vision
Occasional: Rash, pruritus, edema, fatigue, abnormal liver enzymes
Serious/Rare:

• Hepatotoxicity (hepatitis, liver failure)
• Congestive heart failure, arrhythmias
• Pulmonary edema
• Severe hypersensitivity reactions

✔️ Words of Advice:

• Take around the same time each day, with food (capsules) or on an empty stomach (oral solution)
• Maintain good hygiene to prevent reinfection
• Do not stop therapy early, even if symptoms improve
• Report persistent side effects (rash, jaundice, swelling, palpitations) immediately

✔️ Drug Interactions

Alcohol: Interaction not well established – consult a doctor before use.

Medicines that decrease Itraconazole levels:

• Carbamazepine, rifampin, rifabutin, phenytoin, phenobarbital, didanosine, and isoniazid
• Acid suppressants (antacids, H2-blockers like ranitidine/cimetidine, PPIs like omeprazole, sucralfate) → reduce absorption

Medicines that increase risk of toxicity (CYP3A4 inhibition):

• Statins (lovastatin, simvastatin, atorvastatin) → risk of rhabdomyolysis
• Cyclosporine, tacrolimus → increased serum levels
• Digoxin, phenytoin, warfarin → increased plasma concentration
• Protease inhibitors, benzodiazepines, corticosteroids, oral hypoglycemics, calcium channel blockers (e.g., amlodipine) → increased effects
• Astemizole, cisapride, terfenadine, vinca alkaloids → risk of QT prolongation, torsades de pointes, and cardiotoxicity (concomitant use contraindicated)

✔️ Interaction

Liver disease: Monitor LFTs closely; discontinue if hepatotoxicity develops

Heart disease: Risk of congestive heart failure, arrhythmia, or torsade de pointes – avoid in CHF patients

Renal impairment: Use with caution, dose adjustment required

Lung disease: Inform the physician before use

✔️ Precautions

• Avoid antacids or acid-blockers within 2 hours of dosing
• Can cause dizziness or blurred vision → avoid driving or hazardous work until response is known
• Pregnancy & Lactation: Not recommended; use only if necessary under medical supervision
• Diabetes: Monitor blood glucose (risk of hypoglycemia when combined with sulfonylureas)
• Prolonged use (>1 month) may require regular blood tests for liver/kidney monitoring

✔️ Storage:

Store at room temperature, away from excess heat and moisture.